The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Regulatory T cells (Treg cells) are essential for immune tolerance, but also drive
immunosuppression in the tumour microenvironment. Therapeutic targeting of Treg cells in …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the
molecular mechanisms linking the mevalonate pathway to inflammation remain obscure …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …

Objective—The calcium composition of atherosclerotic plaque is thought to be associated
with increased risk for cardiovascular events, but whether plaque calcium itself is predictive …

Hypoxia and low glucose abundance often occur simultaneously at sites of inflammation. In
monocytes and macrophages, glucose-oxygen deprivation stimulates the assembly of the …

Regulatory B cells restrict immune and inflammatory responses across a number of contexts.
This capacity is mediated primarily through the production of IL-10. Here we demonstrate …