Permeation of the cell membrane leading to cell death is a mechanism used by a large
number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one …

Antimicrobial peptides encompass a wide variety of structural motifs. Many peptides have α-
helical structures. The majority of these peptides are cationic and amphipathic but there are …

Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

The introduction of antibiotics into clinical practice revolutionized the treatment and
management of infectious diseases. Before the introduction of antibiotics, these diseases …

This review addresses the possible consequences of a mismatch in length between the
hydrophobic part of membrane-spanning proteins and the hydrophobic bilayer thickness for …

Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the
plasma membranes of eukaryotic cells. While successful intracellular delivery of many …

Abstract Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the
thermotropic properties of many different biological macromolecules and extracts. Since its …

Magainin 2, an antimicrobial peptide from the Xenopus skin, kills bacteria by permeabilizing
the cell membranes. We have proposed that the peptide preferentially interacts with acidic …

Living organisms of all types produce a large repertoire of gene-encoded, net positively
charged, antimicrobial peptides as part of their innate immunity to microbial invasion …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …