The ArcAB two-component system: function in metabolism, redox control, and infection

AN Brown, MT Anderson, MA Bachman… - Microbiology and …, 2022 - Am Soc Microbiol
ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function

BJ Burkhart, CJ Schwalen, G Mann, JH Naismith… - Chemical …, 2017 - ACS Publications
With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression

CJ Dorman, MJ Dorman - Biophysical reviews, 2016 - Springer
Although it has become routine to consider DNA in terms of its role as a carrier of genetic
information, it is also an important contributor to the control of gene expression. This …

Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs

M Guillier, S Gottesman - Molecular microbiology, 2006 - Wiley Online Library
Small non‐coding RNAs that play important regulatory roles exist in numerous organisms. In
Escherichia coli, about 60 small RNAs have been found and those that have been studied …

Antibiotic-Inducible Promoter Regulated by the Cell Envelope Stress-Sensing Two-Component System LiaRS of Bacillus subtilis

T Mascher, SL Zimmer, TA Smith… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Soil bacteria are among the most prodigious producers of antibiotics. The Bacillus subtilis
LiaRS (formerly YvqCE) two-component system is one of several antibiotic-sensing systems …

Progress overview of bacterial two-component regulatory systems as potential targets for antimicrobial chemotherapy

H Hirakawa, J Kurushima, Y Hashimoto, H Tomita - Antibiotics, 2020 - mdpi.com
Bacteria adapt to changes in their environment using a mechanism known as the two-
component regulatory system (TCS)(also called “two-component signal transduction system” …

EnvZ/OmpR two-component signaling: an archetype system that can function noncanonically

LJ Kenney, GS Anand - EcoSal Plus, 2020 - Am Soc Microbiol
Two-component regulatory systems represent the major paradigm for signal transduction in
prokaryotes. The simplest systems are composed of a sensor kinase and a response …

Biologically inspired strategies for combating bacterial biofilms

MS Blackledge, RJ Worthington, C Melander - Current opinion in …, 2013 - Elsevier
Highlights•Biofilms are inherently resistant to antibiotics and are a major health
threat.•Quorum sensing antagonists inhibit biofilm formation.•Inhibition of two-component …

Complex regulation of csgD promoter activity by global regulatory proteins

U Gerstel, C Park, U Römling - Molecular microbiology, 2003 - Wiley Online Library
The starvation‐induced csgD gene of Salmonella typhimurium encodes for the positive
transcriptional regulator of extracellular matrix components curli fimbriae and cellulose. To …

The Escherichia coli CpxA-CpxR Envelope Stress Response System Regulates Expression of the Porins OmpF and OmpC

E Batchelor, D Walthers, LJ Kenney… - Journal of …, 2005 - Am Soc Microbiol
We performed transposon mutagenesis of a two-color fluorescent reporter strain to identify
new regulators of the porin genes ompF and ompC in Escherichia coli. Screening of …