In-situ multi-phase flow imaging for particle dynamic tracking and characterization: Advances and applications
Real-time chemical process monitoring, analysis, and control have become increasingly
important to multi-phase flow process research and development and attracted overt …
important to multi-phase flow process research and development and attracted overt …
[HTML][HTML] Application of PAT-based feedback control approaches in pharmaceutical crystallization
Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications
Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …
drive toward the transition from exclusive batch manufacturing to integrated continuous …
Recent progress in continuous crystallization of pharmaceutical products: precise preparation and control
Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …
great diversity of crystalline pharmaceutical products. In recent years, continuous …
Impurity incorporation in solution crystallization: diagnosis, prevention, and control
Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …
solution crystallization processes lack a sufficient understanding on how impurities …
Prevalence of impurity retention mechanisms in pharmaceutical crystallizations
The rejection of process impurities from crystallizing products is an essential step for the
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …
Tuning crystal morphology of succinic acid using a polymer additive
The effect of the triblock copolymer Pluronic P123 (PP123) on the growth of succinic acid
crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The …
crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The …
Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model
The development of a process model for the batch cooling crystallization of an anticancer
drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals …
drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals …
Mechanisms and control of impurities in continuous crystallization: a review
C Darmali, S Mansouri, N Yazdanpanah… - Industrial & …, 2018 - ACS Publications
Crystallization has been applied to a broad range of industries such as bulk and fine
chemicals and the pharmaceutical and food industries. It is important to strategically control …
chemicals and the pharmaceutical and food industries. It is important to strategically control …
[HTML][HTML] Image analysis framework with focus evaluation for in situ characterisation of particle size and shape attributes
Particle processing industries, such as pharmaceutical, food processing and consumer
goods sectors, increasingly require strategies to control and engineer particle attributes. In …
goods sectors, increasingly require strategies to control and engineer particle attributes. In …