Schizophrenia is a complex psychiatric disorder where genetic, epigenetic, and
environmental factors play a role in disease onset, course of illness, and treatment outcome …

Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …

Background Behavioral phenotypical continua from health to disease suggest common
underlying mechanisms with quantitative rather than qualitative differences. Until recently …

Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their
benefit/risk ratio. We sought to identify common variants in genes which predict response to …

GABA (γ-aminobutyric acid) is the main neurotransmitter at inhibitory synapses in the
mammalian brain. It is essential for maintaining the excitation and inhibition (E/I) ratio …

Abstract Major Depressive Disorder (MDD) is a pleomorphic disease with substantial
patterns of symptoms and severity with mensurable deficits in several associated domains …

Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disorder of aging, was long believed to be a non-genetic sporadic origin …

Abstract Neurexin 1 (NRXN1), a presynaptic cell adhesion molecule, is implicated in several
neurodevelopmental disorders characterized by synaptic dysfunction including autism …

Osteoarthritis (OA) and major depression (MD) are two debilitating disorders that frequently
co-occur and affect millions of the elderly each year. Despite the greater symptom severity …

Schizophrenia is a chronic psychiatric disorder with complex genetic and environmental
origins. While many antipsychotics have been demonstrated as effective in the treatment of …