Staphylococcus aureus biofilm: a complex developmental organism

DE Moormeier, KW Bayles - Molecular microbiology, 2017‏ - Wiley Online Library
Chronic biofilm‐associated infections caused by Staphylococcus aureus often lead to
significant increases in morbidity and mortality, particularly when associated with indwelling …

Within-host evolution of bacterial pathogens

X Didelot, AS Walker, TE Peto, DW Crook… - Nature Reviews …, 2016‏ - nature.com
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Genomic infectious disease epidemiology in partially sampled and ongoing outbreaks

X Didelot, C Fraser, J Gardy… - Molecular biology and …, 2017‏ - academic.oup.com
Genomic data are increasingly being used to understand infectious disease epidemiology.
Isolates from a given outbreak are sequenced, and the patterns of shared variation are used …

Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis

F Coll, KE Raven, GM Knight, B Blane… - The Lancet …, 2020‏ - thelancet.com
Background Whole-genome sequencing (WGS) can be used in genomic epidemiology
investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted …

Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in an intensive care unit: a longitudinal cohort study based on …

JR Price, K Cole, A Bexley, V Kostiou… - The Lancet Infectious …, 2017‏ - thelancet.com
Background Health-care workers have been implicated in nosocomial outbreaks of
Staphylococcus aureus, but the dearth of evidence from non-outbreak situations means that …

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

Y Nakamura, H Takahashi, A Takaya, Y Inoue… - Science translational …, 2020‏ - science.org
Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus
in the affected skin. To understand the role of S. aureus in the development of AD, we …

A year of infection in the intensive care unit: prospective whole genome sequencing of bacterial clinical isolates reveals cryptic transmissions and novel microbiota

DJ Roach, JN Burton, C Lee, B Stackhouse… - PLoS …, 2015‏ - journals.plos.org
Bacterial whole genome sequencing holds promise as a disruptive technology in clinical
microbiology, but it has not yet been applied systematically or comprehensively within a …

Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community

F Coll, EM Harrison, MS Toleman, S Reuter… - Science translational …, 2017‏ - science.org
Genome sequencing has provided snapshots of the transmission of methicillin-resistant
Staphylococcus aureus (MRSA) during suspected outbreaks in isolated hospital wards …

Whole-genome sequencing as part of national and international surveillance programmes for antimicrobial resistance: a roadmap

NIHR Global Health Research Unit on Genomic … - BMJ global …, 2020‏ - gh.bmj.com
The global spread of antimicrobial resistance (AMR) and lack of novel alternative treatments
have been declared a global public health emergency by WHO. The greatest impact of AMR …

Whole-genome sequencing targets drug-resistant bacterial infections

NV Punina, NM Makridakis, MA Remnev, AF Topunov - Human genomics, 2015‏ - Springer
During the past two decades, the technological progress of whole-genome sequencing
(WGS) had changed the fields of Environmental Microbiology and Biotechnology, and …