Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–
22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in …

Renal fibrosis is the common pathological feature in a variety of chronic kidney diseases.
Aging is highly associated with the progression of renal fibrosis. Among several …

Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive
syndrome and increased number of older people. Sarcopenia is defined by decreased …

Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic
oxidative stress is an important factor contributes to the postmenopausal osteoporosis …

The pathogenesis of declining bone mineral density, a universal feature of ageing, is not
fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in …

Stem cells have the unique capacity to differentiate into many cell types during embryonic
development and postnatal growth. Through coordinated cellular behaviors (self‐renewal …

Mesenchymal stem cells (MSCs) are characterized to have the capacity of self-renewal and
the potential to differentiate into mesoderm, ectoderm-like and endoderm-like cells. MSCs …

Energy metabolism plays an important role in cell and tissue ability to effectively function,
maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal …

Here, we developed an isogenic cell model of “stemness” to facilitate protein biomarker
discovery in breast cancer. For this purpose, we used knowledge gained previously from the …