Functional annotation of genomes is a prerequisite for contemporary basic and applied
genomic research, yet farmed animal genomics is deficient in such annotation. To address …

The number of known pathologies involving deregulated Tau expression/metabolism is
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …

Single-cell RNAseq and alternative splicing studies have recently become two of the most
prominent applications of RNAseq. However, the combination of both is still challenging …

Specialized RNA-seq methods are required to identify the 5′ ends of transcripts, which are
critical for studies of gene regulation, but these methods have not been systematically …

Background Numerous long non-coding RNAs (lncRNAs) have been identified and their
roles in gene regulation in humans, mice, and other model organisms studied; however, far …

GENCODE produces comprehensive reference gene annotation for human and mouse.
Entering its twentieth year, the project remains highly active as new technologies and …

Alu elements are one of the most successful families of transposons in the human genome.
A portion of Alu elements is transcribed by RNA Pol III, whereas the remaining ones are part …

Many plant disease resistance (R) genes function specifically in reaction to the presence of
cognate effectors from a pathogen. Xanthomonas oryzae pathovar oryzae (Xoo) uses …

The perception of adipose tissue, both in the scientific community and in the general
population, has changed dramatically in the past 20 years. While adipose tissue was …

SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through
post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive …