Natural killer group 2 member D (NKG2D) is a type II transmembrane receptor. NKG2D is
present on NK cells in both mice and humans, whereas it is constitutively expressed on …

It is well known that F-actin dynamics drive the micron-scale cell shape changes required for
migration and immunological synapse (IS) formation. In addition, recent evidence points to a …

Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer. In the
United States it is second leading cause of cancer related deaths in men. PCa is often …

Actin is an important cytoskeletal protein involved in signal transduction, cell structure and
motility. Actin regulators include actin-monomer-binding proteins, Wiskott-Aldrich syndrome …

Abstract Cell division cycle 42 (CDC42) regulates immune escape, which predicts immune
checkpoint inhibitor (ICI) treatment response in several types of cancer. The present study …

Antibody therapy targeting cytotoxic T lymphocyte–associated antigen 4 (CTLA4) elicited
survival benefits in cancer patients; however, the overall response rate is limited. In addition …

Over the last decades, research dedicated to the molecular and cellular mechanisms
underlying primary immunodeficiencies (PID) has helped to understand the etiology of many …

This review is focused on mechanisms of chemokine-induced polarization of T-lymphocytes.
Polarization involves, starting from spherical cells, formation of a morphologically and …

Background NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and
CD8+ T cells. The existence of an atypical cytotoxic CD4+ NKG2D+ T cell population has …

Abstract NK1. 1-CD4+ NKG2D+ cells exert their immune-regulatory function in tumor as an
unconventional regulatory T cell subset through the production of TGF-β1; however, the …