Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of
liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment …

BACKGROUND Patients with metastatic sarcomas have poor outcomes and although the
disease may be amenable to immunotherapies, information regarding the immunologic …

Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by multiple café au lait
macules, intertriginous freckling, multiple cutaneous neurofibromas, and learning disability …

Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma
subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a …

Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an
overall incidence of about five per 100,000 per year. While this diverse family of …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Abstract Analysis of selected cancer genes has become an important tool in precision
oncology but cannot fully capture the molecular features and, most importantly …

Dedifferentiated liposarcoma (DDL) is defined as the transition from well-differentiated
liposarcoma (WDL)/atypical lipomatous tumor (ALT) to non-lipogenic sarcoma, which arises …