Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …

Mitochondrial functions are essential for life, critical for development, maintenance of stem
cells, adaptation to physiological changes, responses to stress, and aging. The complexity of …

Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells
and involved in intercellular communication through transfer of proteins and genetic …

Prohibitins are the central regulatory element of cellular homeostasis, especially by
modulating the response at different levels: Nucleus, mitochondria and membranes. Their …

Glioblastoma multiforme (GBM) is the most aggressive form of adult primary malignant brain
tumour with poor prognosis. Extracellular vesicles (EVs) are a key-mediator through which …

Glioblastoma multiforme (GBM) is the most common and aggressive form of primary
malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key …

The mitochondrial inner membrane proteins OMA1 and OPA1 belong to the BAX/BAK1‐
dependent apoptotic signaling pathway, which can be regulated by tumor protein p53 and …

Fluorizoline is a new synthetic molecule that induces p53‐independent apoptosis, in several
tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In …

Abstract Prohibitins 1 and 2 (PHB1/2) are scaffold proteins that are involved in both
melanogenesis and oncogenic pathways. We hypothesized that a PHB1 ligand …

Background Melanoma is the most lethal type of skin cancer. Since chemoresistance is a
significant barrier, identification of regulators affecting chemosensitivity is necessary in order …