Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …

T cells in the immune system protect the human body from infection by pathogens and clear
mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy …

Background In patients undergoing allogeneic hematopoietic stem-cell transplantation
(HSCT), a calcineurin inhibitor plus methotrexate has been a standard prophylaxis against …

Background Acute graft-versus-host disease (GVHD) remains a major limitation of
allogeneic stem-cell transplantation; not all patients have a response to standard …

Microbial transformation of bile acids affects intestinal immune homoeostasis but its impact
on inflammatory pathologies remains largely unknown. Using a mouse model of graft-versus …

Background Responses to conventional donor lymphocyte infusion for postallogeneic
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell …

Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic
hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited …

Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a major
cause of morbidity and mortality in patients receiving allogeneic hematopoietic stem cell …

Patients who develop steroid-refractory acute graft-versus-host disease (aGVHD) after
allogeneic hematopoietic cell transplantation have poor prognosis, highlighting an unmet …

The diversity of the human microbiome heralds the difference of the impact that gut microbial
metabolites exert on allogenic graft-versus-host (GVH) disease (GVHD), even though short …