Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Myeloid cell leukemia sequence 1 (MCL-1) is an antiapoptotic protein that plays a key role in
promoting cell survival in multiple myeloma (MM), acute myeloid leukemia (AML), and non …

Background No targeted drugs are currently available against small cell lung cancer
(SCLC). BCL-2 family members are involved in apoptosis regulation and represent …

MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from
other family members based on its relatively short half-life. Emerging studies have revealed …

Heavy metal cadmium (Cd), a classical environmental pollutant, causes placental apoptosis
and fetal growth restriction (FGR), whereby the mechanism remains unclear. Here, our …

Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …

The internal tandem duplication of the juxtamembrane domain of the FMS-like tyrosine
kinase 3 (FLT3-ITD) is the most common genetic change in acute myeloid leukemia (AML) …

The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …