Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

Seaweed-derived polysaccharides including agar and alginate, have found widespread
applications in biomedical research and medical therapeutic applications including wound …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of
heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated
with colon cancer. Expression of the enzyme heparanase is clearly linked to colon …

Elastic and collagen fibers are well known to be the major load-bearing extracellular matrix
(ECM) components of the arterial wall. Studies of the structural components and mechanics …

Fluid shear stresses are potent regulators of vascular homeostasis and powerful
determinants of vascular disease progression. The glycocalyx is a layer of …

Heparanase is the only known mammalian endoglycosidase capable of degrading heparan
sulfate glycosaminoglycan, both in extracellular space and within the cells. It is tightly …

Objective—Factors and mechanisms that activate macrophages in atherosclerotic plaques
are incompletely understood. We examined the capacity of heparanase to activate …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
its management places a huge burden on healthcare systems through hospitalisation and …