Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …

Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …

Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for
preclinical studies and therapeutic testing. It has been proposed that the mouse host affects …

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …

Pediatric patients with recurrent and refractory cancers are in most need for new treatments.
This study developed patient-derived-xenograft (PDX) models within the European …

Establishing appropriate preclinical models is essential for cancer research. Evidence
suggests that cancer is a highly heterogeneous disease. This follows the growing use of …

Although systemic chemotherapy remains the standard of care for TNBC, even combination
chemotherapy is often ineffective. The identification of biomarkers for differential …

Historically, human breast cancer has been modeled largely in vitro using long-established
cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of …