Ring-cleaving dioxygenases catalyze the oxygenolytic fission of catecholic compounds, a
critical step in the aerobic degradation of aromatic compounds by bacteria. Two classes of …

Ring-cleaving dioxygenases catalyze key reactions in the aerobic microbial degradation of
aromatic compounds. Many pathways converge to catecholic intermediates, which are …

The uncatalyzed reactions of O2 (S= 1) with organic substrates (S= 0) are
thermodynamically favorable but kinetically slow because they are spin-forbidden and the …

Here, the choice of the first coordination shell of the metal center is analyzed from the
perspective of charge maintenance in a binary enzyme–substrate complex and an O2 …

Mononuclear iron (II)− and iron (III)− catecholato complexes with three members of a new 3,
3-bis (1-alkylimidazol-2-yl) propionate ligand family have been synthesized as models of the …

The mechanism of the catalytic reaction of protocatechuate 3, 4-dioxygenase (3, 4-PCD), a
representative intradiol dioxygenase, was studied with the hybrid density functional method …

Various mechanisms have been proposed for the initial O2 attack in intradiol dioxygenases
based on different electronic descriptions of the enzyme− substrate (ES) complex. We have …

LigAB from Sphingomonas paucimobilis SYK-6 is the only structurally characterized
dioxygenase of the largely uncharacterized superfamily of Type II extradiol dioxygenases …

Luminescent lanthanide optical sensors have been developed that utilize ancillary ligands
to enhance detection of a target analyte. In these systems, the lanthanide (ligand) binary …

Dihydroxypridine dioxygenase (NicX) catalyzes an aromatic N-heterocylic ring opening. We
renew reaction mechanisms of NicX and discover a competitive dioxetane pathway …