Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD) is
increasing rapidly with the continuous growth of the economy. A large number of studies …

The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

Food components in our diet provide not only necessary nutrients to our body but also
substrates for the mutualistic microbial flora in our gastrointestinal tract, termed the gut …

Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …

Crohn's disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of
the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although …

The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host
immunity and maintain homeostasis. Loss-of-function mutations in NOD2 are associated …

Gastrointestinal cancer is currently one of the main causes of cancer death, with a large
number of cases and a wide range of lesioned sites. A high fat diet, as a public health …

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the
formation of nodules, abscesses, and fistulae at intertriginous sites. The skin–gut axis is an …

Abstract Inflammatory Bowel Disease (IBD) is a chronic relapsing-remitting disease with a
remarkable increase in incidence worldwide and a substantial disease burden. Although the …

Recent advances in our understanding of the pathogenesis of inflammatory bowel disease
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …