Cross‐Coupling of Heteroarenes by C H Functionalization: Recent Progress towards Direct Arylation and Heteroarylation Reactions Involving Heteroarenes …
In recent years, transition metal‐catalyzed direct (hetero) arylation reactions of heteroarenes
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
Mitigating risk in academic preclinical drug discovery
The number of academic drug discovery centres has grown considerably in recent years,
providing new opportunities to couple the curiosity-driven research culture in academia with …
providing new opportunities to couple the curiosity-driven research culture in academia with …
PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS
Significant resources in early drug discovery are spent unknowingly pursuing artifacts and
promiscuous bioactive compounds, while understanding the chemical basis for these …
promiscuous bioactive compounds, while understanding the chemical basis for these …
Battle against vancomycin-resistant bacteria: recent developments in chemical strategies
Vancomycin, a natural glycopeptide antibiotic, was used as the antibiotic of last resort for the
treatment of multidrug-resistant Gram-positive bacterial infections. However, almost 30 years …
treatment of multidrug-resistant Gram-positive bacterial infections. However, almost 30 years …
Multidrug-resistant enterococcal infections: new compounds, novel antimicrobial therapies?
Over the past two decades infections due to antibiotic-resistant bacteria have escalated
world-wide, affecting patient morbidity, mortality, and health care costs. Among these …
world-wide, affecting patient morbidity, mortality, and health care costs. Among these …
Transition Metal‐Free Direct C H (Hetero) arylation of Heteroarenes: A Sustainable Methodology to Access (Hetero) aryl‐Substituted Heteroarenes
R Rossi, M Lessi, C Manzini… - … Synthesis & Catalysis, 2015 - Wiley Online Library
In recent years, environmental and economic reasons have motivated the development of
transition metal‐free carbon‐carbon bond forming reactions and some excellent reviews …
transition metal‐free carbon‐carbon bond forming reactions and some excellent reviews …
Virtual screening and antimicrobial evaluation for identification of natural compounds as the prospective inhibitors of antibacterial drug resistance targets in …
Infectious diseases have remained a burgeoning cause of death and disability since long.
Staphylococcus aureus (S. aureus) is a severe bacterial pathogen causing nosocomial and …
Staphylococcus aureus (S. aureus) is a severe bacterial pathogen causing nosocomial and …
Promising antibacterial agents against multidrug resistant Staphylococcus aureus
Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a
critical health menace universally. Resistance to all the available chemotherapeutics has …
critical health menace universally. Resistance to all the available chemotherapeutics has …
Base-Promoted Formal [3+ 2] Cycloaddition of α-Halohydroxamates with Carbon Disulfide to Synthesize Polysubstituted Rhodanines
X Lei, J Feng, Q Guo, C Xu, J Shi - Organic Letters, 2022 - ACS Publications
A concise and practical strategy via potassium-carbonate-mediated [3+ 2]-cycloaddition
reaction of α-halohydroxamates with the common solvent carbon disulfide for the synthesis …
reaction of α-halohydroxamates with the common solvent carbon disulfide for the synthesis …
Anti-tuberculosis mur inhibitors: structural insights and the way ahead for development of novel agents
Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …