Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

Fucosylation is a biological process broadly observed in vertebrates, invertebrates, plants,
bacteria, and fungi. Fucose moieties on cell-surface glycans are increasingly recognized as …

The B cell receptor (BCR) initiates immune responses through antigen recognition. We
report a 3.3-angstrom cryo–electron microscopy structure of human immunoglobulin M (IgM) …

Immunological memory is the key source of protective immunity against pathogens. At the
current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral …

Abstract Transmembrane protein 30A (TMEM30A) maintains the asymmetric distribution of
phosphatidylserine, an integral component of the cell membrane and 'eat-me'signal …

The immune system is strictly regulated by glycosylation through the addition of highly
diverse and dynamically changing sugar structures (glycans) to the majority of immune cell …

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This
may be of particular importance in the context of immune receptors, such as the B cell …

Subunit vaccines based on antigen proteins or epitopes of pathogens or tumors show
advantages in immunological precision and high safety, but are often limited by their low …

In the vertebrate immune system, each B-lymphocyte expresses a surface IgM-class B cell
receptor (BCR). When cross-linked by antigen or anti-IgM antibody, the BCR accumulates …

For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of
researchers seeking to find novel immunotherapies to treat cancer. CARs were first …