J-Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge
The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early
repolarization syndrome (ERS), have captured the interest of the cardiology community over …
repolarization syndrome (ERS), have captured the interest of the cardiology community over …
J wave syndromes
The J wave, also referred to as an Osborn wave, is a deflection immediately following the
QRS complex of the surface ECG. When partially buried in the R wave, the J wave appears …
QRS complex of the surface ECG. When partially buried in the R wave, the J wave appears …
Reappraisal of reported genes for sudden arrhythmic death: evidence-based evaluation of gene validity for Brugada syndrome
Background: Implicit in the genetic evaluation of patients with suspected genetic diseases is
the assumption that the genes evaluated are causative for the disease based on robust …
the assumption that the genes evaluated are causative for the disease based on robust …
Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement
J Brugada, N Blom, G Sarquella-Brugada… - Europace, 2013 - academic.oup.com
In children with structurally normal hearts, the mechanisms of arrhythmias are usually the
same as in the adult patient. Some arrhythmias are particularly associated with young age …
same as in the adult patient. Some arrhythmias are particularly associated with young age …
Overview of basic mechanisms of cardiac arrhythmia
C Antzelevitch, A Burashnikov - Cardiac …, 2011 - cardiacep.theclinics.com
A cardiac arrhythmia simply defined is a variation from the normal heart rate and/or rhythm
that is not physiologically justified. Recent years have witnessed important advances in our …
that is not physiologically justified. Recent years have witnessed important advances in our …
An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing
JD Kapplinger, DJ Tester, M Alders, B Benito, M Berthet… - Heart rhythm, 2010 - Elsevier
BACKGROUND: Brugada syndrome (BrS) is a common heritable channelopathy. Mutations
in the SCN5A-encoded sodium channel (BrS1) culminate in the most common genotype …
in the SCN5A-encoded sodium channel (BrS1) culminate in the most common genotype …
[HTML][HTML] Ion channels in the heart
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death
BACKGROUND: L-type calcium channel (LTCC) mutations have been associated with
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …
Neurological perspectives on voltage-gated sodium channels
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …
Na+ Channel β Subunits: Overachievers of the Ion Channel Family
Voltage-gated Na+ channels (VGSCs) in mammals contain a pore-forming α subunit and
one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and …
one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and …