Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements

CD Nelson, TA Reinhardt, JD Lippolis, RE Sacco… - Nutrients, 2012 - mdpi.com
The endocrine physiology of vitamin D in cattle has been rigorously investigated and has
yielded information on vitamin D requirements, endocrine function in health and disease …

Host Response to Leptospira Infection

RL Zuerner - Leptospira and Leptospirosis, 2014 - Springer
Pathogenic Leptospira has the capacity to infect a broad range of mammalian hosts.
Leptospirosis may appear as an acute, potentially fatal infection in accidental hosts, or …

γδ T cell function varies with the expressed WC1 coreceptor

AN Rogers, DG VanBuren, EE Hedblom… - The Journal of …, 2005 - journals.aai.org
WC1 molecules are transmembrane glycoproteins belonging to the scavenger receptor
cysteine-rich family and uniquely expressed on γδ T cells. Although participation of WC1+ γδ …

Subpopulations of bovine WC1+ γδ T cells rather than CD4+ CD25highFoxp3+ T cells act as immune regulatory cells ex vivo

A Hoek, VPMG Rutten, J Kool… - Veterinary …, 2008 - pmc.ncbi.nlm.nih.gov
Regulatory T cells (Treg) are regarded essential components for maintenance of immune
homeostasis. Especially CD4+ CD25high T cells are considered to be important regulators …

Characterization of the domestic goat γδ T cell receptor gene loci and gene usage

A Gillespie, A Yirsaw, KP Gunasekaran, TP Smith… - Immunogenetics, 2021 - Springer
Goats and cattle diverged 30 million years ago but retain similarities in immune system
genes. Here, the caprine T cell receptor (TCR) gene loci and transcription of its genes were …

Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation

CL Roark, MK Aydintug, J Lewis, X Yin… - Journal of Leucocyte …, 2004 - academic.oup.com
The Vγ6/Vδ1+ cells, the second murine γδ T cell subset to arise in the thymus, express a
nearly invariant T cell receptor (TCR), colonize select tissues, and expand preferentially in …

A Leptospira borgpetersenii serovar Hardjo vaccine induces a Th1 response, activates NK cells, and reduces renal colonization

RL Zuerner, DP Alt, MV Palmer… - Clinical and vaccine …, 2011 - Am Soc Microbiol
Chronic infection of cattle with Leptospira borgpetersenii serovar Hardjo reduces animal
production through reproductive failure and presents a persistent health threat to workers in …

Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters

SM Faisal, WW Yan, CS Chen, RUM Palaniappan… - Vaccine, 2008 - Elsevier
We demonstrated earlier that immunization with recombinant Leptospira immunoglobulin
like protein A (LigA) induced significant protection against virulent Leptospira interrogans …

Comparison of three different leptospiral vaccines for induction of a type 1 immune response to Leptospira borgpetersenii serovar Hardjo

RA Brown, S Blumerman, C Gay, C Bolin, R Duby… - Vaccine, 2003 - Elsevier
Leptospira serovar Hardjo are bacterial pathogens of cattle that cause zoonotic infections of
humans. Monovalent serovar Hardjo vaccines protect cattle from serovar Hardjo while …

Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCRγδ+ T cells vs TCRαβ+ T cells

GR Klimpel, MA Matthias, JM Vinetz - The Journal of Immunology, 2003 - journals.aai.org
Innate and adaptive immune responses induced by leptospirosis have not been well
characterized. In this study we show that in vitro exposure of naive human PBMC to …