Computational modeling of cardiac hemodynamics: current status and future outlook
The proliferation of four-dimensional imaging technologies, increasing computational
speeds, improved simulation algorithms, and the widespread availability of powerful …
speeds, improved simulation algorithms, and the widespread availability of powerful …
Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models
Sudden cardiac death (SCD) from arrhythmias is a leading cause of mortality. For patients at
high SCD risk, prophylactic insertion of implantable cardioverter defibrillators (ICDs) reduces …
high SCD risk, prophylactic insertion of implantable cardioverter defibrillators (ICDs) reduces …
Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia
Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in
patients with myocardial infarction. Catheter-based radio-frequency ablation of cardiac …
patients with myocardial infarction. Catheter-based radio-frequency ablation of cardiac …
Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …
the current development of clinical diagnostics to more accurately measure the extent and …
Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations
Ventricular arrhythmias are among the most severe complications of heart disease and can
result in sudden cardiac death. Patients at risk currently receive implantable defibrillators …
result in sudden cardiac death. Patients at risk currently receive implantable defibrillators …
Fat infiltration in the infarcted heart as a paradigm for ventricular arrhythmias
Infiltrating adipose tissue (inFAT) has been recently found to co-localize with scar in
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …
Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy
JF Dawkins, A Ehdaie, R Rogers… - European heart …, 2022 - academic.oup.com
Aims Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden cardiac
death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly …
death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly …
Personalized computational heart models with T1-mapped fibrotic remodeling predict sudden death risk in patients with hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD)
due to ventricular arrhythmias (VAs) arising from the proliferation of fibrosis in the heart …
due to ventricular arrhythmias (VAs) arising from the proliferation of fibrosis in the heart …
[HTML][HTML] Images as drivers of progress in cardiac computational modelling
Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …
evolving to cover multiple scales and physical mechanisms. They are moving towards …
Imaging-based simulations for predicting sudden death and guiding ventricular tachycardia ablation
VT ablation in patients with MI. We present the methodology fundamentals based on cardiac
imaging and computational modeling, outlining important assumptions, followed by a review …
imaging and computational modeling, outlining important assumptions, followed by a review …