Computational modeling of cardiac hemodynamics: current status and future outlook

R Mittal, JH Seo, V Vedula, YJ Choi, H Liu… - Journal of …, 2016 - Elsevier
The proliferation of four-dimensional imaging technologies, increasing computational
speeds, improved simulation algorithms, and the widespread availability of powerful …

Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models

HJ Arevalo, F Vadakkumpadan, E Guallar… - Nature …, 2016 - nature.com
Sudden cardiac death (SCD) from arrhythmias is a leading cause of mortality. For patients at
high SCD risk, prophylactic insertion of implantable cardioverter defibrillators (ICDs) reduces …

Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia

A Prakosa, HJ Arevalo, D Deng, PM Boyle… - Nature biomedical …, 2018 - nature.com
Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in
patients with myocardial infarction. Catheter-based radio-frequency ablation of cardiac …

Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention

Y Zhang, VH Barocas, SA Berceli, CE Clancy… - Annals of biomedical …, 2016 - Springer
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

T Bruegmann, PM Boyle, CC Vogt… - The Journal of …, 2016 - Am Soc Clin Investig
Ventricular arrhythmias are among the most severe complications of heart disease and can
result in sudden cardiac death. Patients at risk currently receive implantable defibrillators …

Fat infiltration in the infarcted heart as a paradigm for ventricular arrhythmias

E Sung, A Prakosa, S Zhou, RD Berger… - Nature cardiovascular …, 2022 - nature.com
Infiltrating adipose tissue (inFAT) has been recently found to co-localize with scar in
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …

Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy

JF Dawkins, A Ehdaie, R Rogers… - European heart …, 2022 - academic.oup.com
Aims Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden cardiac
death. Current therapies to prevent VA include radiofrequency ablation to destroy slowly …

[HTML][HTML] Images as drivers of progress in cardiac computational modelling

P Lamata, R Casero, V Carapella, SA Niederer… - Progress in biophysics …, 2014 - Elsevier
Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …

Imaging-based simulations for predicting sudden death and guiding ventricular tachycardia ablation

NA Trayanova, F Pashakhanloo, KC Wu… - Circulation …, 2017 - Am Heart Assoc
VT ablation in patients with MI. We present the methodology fundamentals based on cardiac
imaging and computational modeling, outlining important assumptions, followed by a review …