Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets

R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023 - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications

F Safri, R Nguyen, S Zerehpooshnesfchi… - Cancer Gene …, 2024 - nature.com
Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma

YT Chan, C Zhang, J Wu, P Lu, L Xu, H Yuan, Y Feng… - Molecular Cancer, 2024 - Springer
Liver cancer is a global health challenge, causing a significant social-economic burden.
Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is …

Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring

J Sun, E Esplugues, A Bort, MP Cardelo… - Nature …, 2024 - nature.com
Due to the rise in overnutrition, the incidence of obesity-induced hepatocellular carcinoma
(HCC) will continue to escalate; however, our understanding of the obesity to HCC …

Cascade signal amplifying strategy for ultrasensitive detection of tumor biomarker by DNAzyme cleaving mediated HCR

H Chen, J Song, Y Li, D Deng, Y Song, X Zhu… - Sensors and Actuators B …, 2024 - Elsevier
Tumor biomarkers are a kind of important biomolecules for aiding cancer diagnosis and
assessing tumor efficacy, among which alpha-fetoprotein (AFP) is a crucial tumor biomarker …

[HTML][HTML] Alpha-fetoprotein: Past, present, and future

YH Yeo, YT Lee, HR Tseng, Y Zhu, S You… - Hepatology …, 2024 - journals.lww.com
Alpha-fetoprotein (AFP) is a glycoprotein that plays an important role in immune regulation
with critical involvement in early human development and maintaining the immune balance …

A high-throughput test enables specific detection of hepatocellular carcinoma

D Cheishvili, C Wong, MM Karim, MG Kibria… - Nature …, 2023 - nature.com
High-throughput tests for early cancer detection can revolutionize public health and reduce
cancer morbidity and mortality. Here we show a DNA methylation signature for …

The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma

Y Lu, B Lin, M Li - Frontiers in Oncology, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized
by high morbidity and mortality rates. Alpha-fetoprotein (AFP) is a glycoprotein synthesized …

Robust Glycoproteomics Platform Reveals a Tetra‐Antennary Site‐Specific Glycan Cap** with Sialyl‐Lewis Antigen for Early Detection of Gastric Cancer

L Liu, L Liu, Y Wang, Z Fang, Y Bian… - Advanced …, 2024 - Wiley Online Library
The lack of efficient biomarkers for the early detection of gastric cancer (GC) contributes to its
high mortality rate, so it is crucial to discover novel diagnostic targets for GC. Recent studies …

[HTML][HTML] Emerging role of circulating cell-free RNA as a non-invasive biomarker for hepatocellular carcinoma

D Shetti, VR Mallela, W Ye, M Sharif… - Critical Reviews in …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high
morbidity and mortality rates. HCC is often detected at advanced stages leading to …