Poly (lactic-co-glycolic acid)(PLGA) is a widely used biodegradable and biocompatible
copolymer in drug delivery systems (DDSs). In this article, we highlight the critical …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

Protein–protein interactions (PPIs) are essential for numerous biological activities, including
signal transduction, transcription control, and metabolism. They play a pivotal role in the …

The validity of protein structures and interactions, whether determined under ideal laboratory
conditions or predicted by AI tools such as Alphafold2, to precisely reflect those found in …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

The improvement of enzyme thermostability is of great significance in the biotechnology
industry. Herein, we modified the C-terminus of β-glucosidase via the computer-aided …

The" precision medicine" project put forward higher requirements for analytical chemistry,
centering on new material development. Given the increasing diversity of complex samples …

Background Cross-linking mass spectrometry (XL-MS) is a powerful technique for detecting
protein–protein interactions (PPIs) and modeling protein structures in a high-throughput …

Cross-linking mass spectrometry (XL-MS) is a powerful tool for elucidating protein structures
and protein–protein interactions (PPIs) at the global scale. However, sensitive XL-MS …

Mass spectrometry (MS)-based proteomics can identify and quantify the differential
abundance of expressed proteins in parallel, and bottom-up proteomic approaches are even …