Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

Breast cancer is one of the most commonly diagnosed cancers around the globe and
accounts for a large proportion of fatalities in women. Despite the advancement in …

Cancer-associated fibroblasts (CAFs) plays an important role in the tumor
microenvironment. The heterogeneity of CAFs affects the effect of CAFs on promoting or …

Tumour metastasis is the major cause of breast cancer mortality. Myricetin, a natural
polyphenol, is found in teas, wines, and berries. The pharmacodynamic action and …

Silibinin, a natural flavanone, derived from the milk thistle plant (Silybum marianum), was
illustrated for several medicinal uses such as liver-protective, anti-oxidant, anti-cancer, anti …

Matrix metalloproteinases (MMPs) have been regarded as major critical molecules assisting
tumor cells during metastasis, for excessive ECM (ECM) degradation, and cancer cell …

Background: Silibinin (SB), the main component of Silymarin (SM), is a natural substance
obtained from the seeds of the milk thistle. SM contains up to 70% of SB as two isoforms: A …