SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …

Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-
19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 …

Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in late 2021 and is characterised
by multiple spike mutations across all spike domains. Here we show that Omicron BA. 1 has …

Proteases, enzymes that hydrolyze peptide bonds, have various applications in medicine,
clinical applications, and pharmaceutical development. They are used in cancer treatment …

Monoclonal antibodies are increasingly used to prevent and treat viral infections and are
pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and …

The SARS-CoV-2 Omicron BA. 1 variant emerged in late 2021 and is characterised by
multiple spike mutations across all spike domains. Here we show that Omicron BA. 1 has …

The family of human-infecting coronaviruses (HCoVs) poses a serious threat to global health
and includes several highly pathogenic strains that cause severe respiratory illnesses. It is …

Age-associated B cells (ABC) accumulate with age and in individuals with different
immunological disorders, including cancer patients treated with immune checkpoint …