[HTML][HTML] The antibiotic resistance crisis, with a focus on the United States
E Martens, AL Demain - The Journal of antibiotics, 2017 - nature.com
Beginning with the discovery of penicillin by Alexander Fleming in the late 1920s, antibiotics
have revolutionized the field of medicine. They have saved millions of lives each year …
have revolutionized the field of medicine. They have saved millions of lives each year …
Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery
Drug-resistant mycobacterial infections are a serious global health challenge, leading to
high mortality and socioeconomic burdens in develo** countries worldwide. New …
high mortality and socioeconomic burdens in develo** countries worldwide. New …
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
Abstract The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received
significant attention as a drug target, however its vulnerability may be affected by its flexibility …
significant attention as a drug target, however its vulnerability may be affected by its flexibility …
The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria
Active efflux of antimicrobial agents is a primary mechanism by which bacterial pathogens
can become multidrug resistant. The combined use of efflux pump inhibitors (EPIs) with …
can become multidrug resistant. The combined use of efflux pump inhibitors (EPIs) with …
Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus
Pathways of bacterial energy metabolism, such as the proton motive force (PMF), have
largely remained unexplored as drug targets, owing to toxicity concerns. Here, we elaborate …
largely remained unexplored as drug targets, owing to toxicity concerns. Here, we elaborate …
Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline
Abstract Drug-resistant (DR)-TB is the major challenge confronting the global TB control
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
Identification of the bacteriophage nucleus protein interaction network
In the arms race between bacteria and bacteriophages (phages), some large-genome
jumbo phages have evolved a protein shell that encloses their replicating genome to protect …
jumbo phages have evolved a protein shell that encloses their replicating genome to protect …
[HTML][HTML] ATP synthase in mycobacteria: special features and implications for a function as drug target
ATP synthase is a ubiquitous enzyme that is largely conserved across the kingdoms of life.
This conservation is in accordance with its central role in chemiosmotic energy conversion, a …
This conservation is in accordance with its central role in chemiosmotic energy conversion, a …
Energetics of pathogenic bacteria and opportunities for drug development
The emergence and spread of drug-resistant pathogens and our inability to develop new
antimicrobials to overcome resistance has inspired scientists to consider new targets for …
antimicrobials to overcome resistance has inspired scientists to consider new targets for …
[HTML][HTML] Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis
The ATP synthase is a multicomponent enzyme that is largely conserved across the
kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by …
kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by …