A Randomized, Parallel, Open‐Label, Single‐Dose and Multiple‐Dose Clinical Trial to Investigate the Pharmacokinetic, Pharmacodynamic, and Safety Profiles of …

J Zhang, G Cao, Y Huo, LL Guarneiri… - The Journal of …, 2025 - Wiley Online Library
Obicetrapib is a selective cholesteryl ester transfer protein (CETP) inhibitor. Previous
research has demonstrated similar pharmacokinetic (PK) responses to single doses of …

Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study

B Su, Z Fan, J Wu, H Zhan - Scientific Reports, 2025 - nature.com
Previous studies have found that dyslipidemia is a risk factor for pancreatic cancer (PC), and
that lipid-lowering drugs may reduce the risk of PC. However, it is not clear whether …

CETP inhibition Reduces Cardiovascular Events by Lowering of Cumulative LDL Exposure: Reconciling Evidence from Human Genetics and Clinical Trials

F Landfors, JJP Kastelein, E Chorell - medRxiv, 2024 - medrxiv.org
Background: Genetic studies consistently demonstrate that individuals born with reduced
Cholesteryl Ester Transfer Protein (CETP) activity experience lower rates of atherosclerotic …

Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease

SC de Ruiter, M van Vugt, C Finan, DE Grobbee… - medRxiv, 2024 - medrxiv.org
relevant tissues and may contain relevant therapeutic leads. We integrated data on urinary
metabolism breakdown products, plasma proteins, atherosclerotic plaque tissue, and single …

Immune cell-mediated CETP gene and the causal relationship with ischemic stroke disease risk: Mendelian randomization analysis with mediation effect assessment

H Yuan, X Feng, J Lin, C Huang, M Huang, C Duan - 2025 - researchsquare.com
Background: The advancement of cholesterol ester transfer protein inhibitors in the
treatment of coronary heart disease (CHD) has thus far failed to produce approved …

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M Huang, C Duan - assets-eu.researchsquare.com
Background: The advancement of cholesterol ester transfer protein inhibitors in the
treatment of coronary heart disease (CHD) has thus far failed to produce approved …

Cholesteryl ester transfer protein inhibition: a pathway to reducing risk of morbidity and promoting longevity

MH Davidson, A Hsieh… - Current Opinion in …, 2024 - journals.lww.com
At present, there is robust clinical evidence to support the benefits of reducing CETP activity
for ASCVD risk reduction, and plausibility exists for the promotion of longevity by reducing …