High-content screening for quantitative cell biology

MM Usaj, EB Styles, AJ Verster, H Friesen, C Boone… - Trends in cell …, 2016 - cell.com
High-content screening (HCS), which combines automated fluorescence microscopy with
quantitative image analysis, allows the acquisition of unbiased multiparametric data at the …

Machine learning in cell biology–teaching computers to recognize phenotypes

C Sommer, DW Gerlich - Journal of cell science, 2013 - journals.biologists.com
Recent advances in microscope automation provide new opportunities for high-throughput
cell biology, such as image-based screening. High-complex image analysis tasks often …

Handcrafted vs. non-handcrafted features for computer vision classification

L Nanni, S Ghidoni, S Brahnam - Pattern recognition, 2017 - Elsevier
This work presents a generic computer vision system designed for exploiting trained deep
Convolutional Neural Networks (CNN) as a generic feature extractor and mixing these …

An artificial intelligence-based stacked ensemble approach for prediction of protein subcellular localization in confocal microscopy images

S Aggarwal, S Gupta, D Gupta, Y Gulzar, S Juneja… - Sustainability, 2023 - mdpi.com
Predicting subcellular protein localization has become a popular topic due to its utility in
understanding disease mechanisms and develo** innovative drugs. With the rapid …

Deep CNNs for microscopic image classification by exploiting transfer learning and feature concatenation

LD Nguyen, D Lin, Z Lin, J Cao - 2018 IEEE international …, 2018 - ieeexplore.ieee.org
Deep convolutional neural networks (CNNs) have become one of the state-of-the-art
methods for image classification in various domains. For biomedical image classification …

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

AR Barr, S Cooper, FS Heldt, F Butera, H Stoy… - Nature …, 2017 - nature.com
Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

Cellular heterogeneity: do differences make a difference?

SJ Altschuler, LF Wu - Cell, 2010 - cell.com
A central challenge of biology is to understand how individual cells process information and
respond to perturbations. Much of our knowledge is based on ensemble measurements …

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

AE Carpenter, TR Jones, MR Lamprecht, C Clarke… - Genome biology, 2006 - Springer
Biologists can now prepare and image thousands of samples per day using automation,
enabling chemical screens and functional genomics (for example, using RNA interference) …

Deep learning is combined with massive-scale citizen science to improve large-scale image classification

DP Sullivan, CF Winsnes, L Åkesson, M Hjelmare… - Nature …, 2018 - nature.com
Pattern recognition and classification of images are key challenges throughout the life
sciences. We combined two approaches for large-scale classification of fluorescence …

High performing ensemble of convolutional neural networks for insect pest image detection

L Nanni, A Manfè, G Maguolo, A Lumini… - Ecological Informatics, 2022 - Elsevier
Pest infestation is a major cause of crop damage and lost revenues worldwide. Automatic
identification of invasive insects would significantly speed up the recognition of pests and …