The number of DNA polymerases identified in each organism has mushroomed in the past
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the
major UV photoproducts in DNA, as well as many other DNA adducts. The early steps of …

An updated inventory of about 150 human DNA repair genes is described. The compilation
includes genes encoding DNA repair enzymes, some genes associated with cellular …

Living organisms are continually under attack from a vast array of DNA-damaging agents
that imperils their genomic integrity. As a consequence, cells posses an army of enzymes to …

Y-Family DNA polymerases specialize in translesion synthesis, bypassing damaged bases
that would otherwise block the normal progression of replication forks. Y-Family …

Polκ is one of many DNA polymerases involved in translesion DNA synthesis (TLS). It
belongs to the Y‐family of polymerases along with Polη, Polι and hREV1. Unlike Polη …

Several low-fidelity DNA polymerases have recently been discovered that are able to
bypass DNA lesions during DNA synthesis in vitro. The efficiency and accuracy of lesion …

The progress of replicative DNA polymerases along the replication fork may be impeded by
the presence of lesions in the genome. One way to circumvent such hurdles involves the …