[HTML][HTML] Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability
The microtubule-associated protein (MAP) TAU is mainly sorted into the axon of healthy
brain neurons. Somatodendritic missorting of TAU is a pathological hallmark of many …
brain neurons. Somatodendritic missorting of TAU is a pathological hallmark of many …
Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes
We generated induced excitatory neurons (iNeurons, iNs) from chimpanzee, bonobo, and
human stem cells by expressing the transcription factor neurogenin-2 (NGN2). Single-cell …
human stem cells by expressing the transcription factor neurogenin-2 (NGN2). Single-cell …
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
The stimulator of interferon genes (STING) pathway has been implicated in
neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral …
neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral …
Efficient derivation of excitatory and inhibitory neurons from human pluripotent stem cells stably expressing direct reprogramming factors
It is essential to generate isolated populations of human neuronal subtypes in order to
understand cell‐type‐specific roles in brain function and susceptibility to disease pathology …
understand cell‐type‐specific roles in brain function and susceptibility to disease pathology …
A closer look to the evolution of neurons in humans and apes using stem-cell-derived model systems
M Schörnig, E Taverna - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The cellular, molecular and functional comparison of neurons from closely related species is
crucial in evolutionary neurobiology. The access to living tissue and post-mortem brains of …
crucial in evolutionary neurobiology. The access to living tissue and post-mortem brains of …
iPSC derived cerebral organoids as a model of tauopathy
CEJ Lovejoy - 2021 - discovery.ucl.ac.uk
Insoluble, hyper-phosphorylated aggregates of tau are a pathological hallmark of a range of
clinically diverse neurodegenerative diseases termed tauopathies, of which Alzheimer's …
clinically diverse neurodegenerative diseases termed tauopathies, of which Alzheimer's …