Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms

A Yiangou, SP Mollan, AJ Sinclair - Nature Reviews Neurology, 2023 - nature.com
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few
years. Previously, IIH was considered a disease exclusively affecting the neuro-ophthalmic …

GLP-1 programs the neurovascular landscape

B Chen, X Yu, C Horvath-Diano, MJ Ortuño… - Cell Metabolism, 2024 - cell.com
Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an
environment of overnutrition. This transformative setting has led to persistent health issues …

The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

JL Mitchell, HS Lyons, JK Walker, A Yiangou, O Grech… - Brain, 2023 - academic.oup.com
Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have
demonstrated a novel strategy to lower intracranial pressure using glucagon-like peptide-1 …

The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes

M Thaller, V Homer, Y Hyder, A Yiangou… - Journal of …, 2023 - Springer
Background There are limited longitudinal data evaluating outcomes in idiopathic
intracranial hypertension (IIH). We aimed to evaluate the long-term outcomes in a real-world …

Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2024 - Springer
The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …

“Idiopathic” intracranial hypertension: An update from neurointerventional research for clinicians

KM Fargen, S Coffman, T Torosian, W Brinjikji… - …, 2023 - journals.sagepub.com
Background The recognition of venous sinus stenosis as a contributing factor in the majority
of patients with idiopathic intracranial hypertension coupled with increasing cerebral …

Association of amount of weight lost after bariatric surgery with intracranial pressure in women with idiopathic intracranial hypertension

SP Mollan, JL Mitchell, A Yiangou, RS Ottridge… - Neurology, 2022 - neurology.org
Background and Objectives The idiopathic intracranial hypertension randomized controlled
weight trial (IIH: WT) established that weight loss through bariatric surgery significantly …

Weight management interventions for adults with idiopathic intracranial hypertension: a systematic review and practice recommendations

S Abbott, F Chan, AA Tahrani, SH Wong, FEJ Campbell… - Neurology, 2023 - neurology.org
Background and Objectives Idiopathic intracranial hypertension (IIH) is associated with
obesity; however, there is a lack of clinical consensus on how to manage weight in IIH. The …

Metabolic dysfunction in new‐onset idiopathic intracranial hypertension: identification of novel biomarkers

JJ Korsbæk, RH Jensen, D Beier, EA Wibroe… - Annals of …, 2024 - Wiley Online Library
Objective Idiopathic intracranial hypertension (IIH) is a neurometabolic disease with an
increasing incidence. The pathophysiology is unknown, but improvement of diagnosis and …

An M dwarf accompanied by a close-in giant orbiter with SPECULOOS

AHMJ Triaud, G Dransfield, T Kagetani… - Monthly Notices of …, 2023 - academic.oup.com
In the last decade, a dozen close-in giant planets have been discovered orbiting stars with
spectral types ranging from M0 to M4, a mystery since known formation pathways do not …