Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Current management of major depression, a common and debilitating disorder with a high
social and personal cost, is far from satisfactory. All available antidepressants act through …

Agomelatine (S20098) displayed p K i values of 6.4 and 6.2 at native (porcine) and cloned,
human (h) 5-hydroxytryptamine (5-HT) 2C receptors, respectively. It also interacted with h5 …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD)
are associated with a lag of onset that can prolong distress and impairment for patients, and …

Abstract Serotonin (5-HT) 2C receptors play an important role in the modulation of
monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion …

Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as
a neutral antagonist at 5‐HT2C receptors. Accumulating evidence in a broad range of …

Circadian rhythm sleep disorders (CRSDs), whether chronic or transient, affect a broad
range of individuals, including many elderly, those with severe visual impairments, shift …