Radiobiological and treatment-related aspects of spatially fractionated radiotherapy
The continuously evolving field of radiotherapy aims to devise and implement techniques
that allow for greater tumour control and better sparing of critical organs. Investigations into …
that allow for greater tumour control and better sparing of critical organs. Investigations into …
Technical aspects of proton minibeam radiation therapy: Minibeam generation and delivery
T Schneider - Physica Medica, 2022 - Elsevier
Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines
the normal tissue sparing of sub-millimetric, spatially fractionated beams with the improved …
the normal tissue sparing of sub-millimetric, spatially fractionated beams with the improved …
Characterizing devices for validation of dose, dose rate, and LET in ultra high dose rate proton irradiations
Background Ultra high dose rate (UHDR) radiotherapy using ridge filter is a new treatment
modality known as conformal FLASH that, when optimized for dose, dose rate (DR), and …
modality known as conformal FLASH that, when optimized for dose, dose rate (DR), and …
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates
Objective. The aim of this study was to investigate the feasibility of online monitoring of
irradiation time (IRT) and scan time for FLASH proton radiotherapy using a pixelated …
irradiation time (IRT) and scan time for FLASH proton radiotherapy using a pixelated …
TVL1-IMPT: optimization of peak-to-valley dose ratio via joint total-variation and L1 dose regularization for spatially fractionated pencil-beam-scanning proton therapy
Purpose Proton minibeam radiation therapy (pMBRT) is a novel proton modality of spatially
fractionated RT. pMBRT can reduce the radiation damage to normal tissues via biological …
fractionated RT. pMBRT can reduce the radiation damage to normal tissues via biological …
Comprehensive dosimetric commissioning of proton minibeam radiotherapy on a single gantry proton system
Background Proton minibeam radiation therapy (pMBRT) can deliver spatially fractionated
dose distributions with submillimeter resolution. These dose distributions exhibit significant …
dose distributions with submillimeter resolution. These dose distributions exhibit significant …
A novel proton counting detector and method for the validation of tissue and implant material maps for Monte Carlo dose calculation
The presence of artificial implants complicates the delivery of proton therapy due to
inaccurate characterization of both the implant and the surrounding tissues. In this work, we …
inaccurate characterization of both the implant and the surrounding tissues. In this work, we …
Characterization of 250 MeV protons from the Varian ProBeam PBS system for FLASH radiation therapy
Shoot-through proton FLASH radiation therapy has been proposed where the highest
energy is extracted from a cyclotron to maximize the dose rate (DR). Although our proton …
energy is extracted from a cyclotron to maximize the dose rate (DR). Although our proton …
Preclinical challenges in proton minibeam radiotherapy: physics and biomedical aspects
G Datzmann, M Sammer, S Girst, M Mayerhofer… - Frontiers in …, 2020 - frontiersin.org
The concept of spatial fractionation in radiotherapy was developed for better sparing of
normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton …
normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton …
Conceptual design of a novel nozzle combined with a clinical proton linac for magnetically focussed minibeams
T Schneider, A Patriarca, A Degiovanni, M Gallas… - Cancers, 2021 - mdpi.com
Simple Summary Proton minibeam radiation therapy (pMBRT) is a novel therapeutic
strategy that combines the tissue sparing potential of submillimetric, spatially fractionated …
strategy that combines the tissue sparing potential of submillimetric, spatially fractionated …