Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Hyaluronic acid (HA), also named hyaluronan, is an omnipresent component of the tissue
microenvironment. It is extensively used to formulate targeted drug delivery systems for …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and
associated disorders, including gastrointestinal cancers, have high morbidity and mortality …

Bladder cancer accounts for high morbidity and mortality around the world and its incidence
rate is suggested to be higher in following years. A number of factors involve in bladder …

Rationale: The NF-E2 related factor 2 (Nrf2)–antioxidant response element (ARE) pathway
is essential for protection against oxidative injury and inflammation including hyperoxia …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays
a critical role in regulating cellular defense against electrophilic and oxidative stress by …

In the year 2000, Hanahan and Weinberg defined the six Hallmarks of Cancer as: self-
sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms …

Purpose To evaluate the role of PPARγ in regulating meibocyte differentiation and lipid
synthesis in a human meibomian gland epithelial cell line (hMGEC). Methods HMGEC were …

Omega‐3 (or n‐3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural
ligands for peroxisome proliferator receptor activator (PPAR) γ and, due to the effects of …