The ESTHER database, dedicated to ESTerases and alpha/beta-Hydrolase Enzymes and
Relatives (https://bioweb. supagro. inra. fr/ESTHER/general? what= index), offers online …

Enediyne natural products are renowned for their potent cytotoxicities but the biosynthesis of
their defining 1, 5-diyne-3-ene core moiety remains largely enigmatic. Since the discovery of …

The enediynes are structurally characterized by a 1, 5-diyne-3-ene motif within a 9-or 10-
membered enediyne core. The anthraquinone-fused enediynes (AFEs) are a subclass of 10 …

The anthraquinone-fused enediynes (AFEs) combine an anthraquinone moiety and a ten-
membered enediyne core capable of generating a cytotoxic diradical species. AFE …

Cytochrome P450 enzymes catalyze a large number of oxidative transformations that are
responsible for natural product synthesis. Recent studies have revealed their unique ability …

Dynemicin A has been the sole prototypical anthraquinone-fused enediyne (AFE) explored
since its discovery in 1989. This study investigates the distinct DNA binding and cleavage …

The naturally occurring enediynes are notable for their complex structures, potent DNA
cleaving ability, and emerging usefulness in cancer chemotherapy. They can be classified …

Anthraquinone-fused enediynes are anticancer natural products featuring a DNA-
intercalating anthraquinone moiety. Despite recent insights into anthraquinone-fused …

Distinct among the enediyne antitumor antibiotics, the dynemicin subgroup is comprised of
two discrete halves, an enediyne and an anthraquinone, but each is ultimately derived from …

Natural products have been important in the discovery of new drugs, but their use is limited
due to issues with accessibility and synthesis. Tetrahydronaphthoquinoline-dione (THNQ …