Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Exposure to microgravity and ionizing radiation during spaceflight missions causes
excessive reactive oxygen species (ROS) production that contributes to cellular stress and …

Ecuador has shown a growth in its scientific production since 2011, representing 85% of the
total historical production. These investigations are reflected in scientific publications, which …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive …

Mitochondria's role as engines and beacons of metabolism and determinants of cellular
health is being redefined through their therapeutic application as “Living Drugs”(LDs) …

Circulating cell-free nucleic acids (ccfNAs) of plasma are a remarkable source of genetic,
epigenetic and transcriptomic materials originating from different cells, tissues and organs of …

The diversity and coexistence of extracellular mitochondria may have a key role in the
maintenance of health and progression of disease. Studies report that active mitochondria …

Abstract l-lactate is a catabolite from the anaerobic metabolism of glucose, which plays a
paramount role as a signaling molecule in various steps of the cell survival. Its activity, as a …

The cerebrospinal fluid (CSF) has an important role in the transport of nutrients and
signaling molecules to the central nervous and immune systems through its circulation along …

Advancing age and environmental stressors lead to mitochondrial dysfunction in the skin,
inducing premature aging, impaired regeneration, and greater risk of cancer. Cells rely on …