Non-specificity as the sticky problem in therapeutic antibody development

H Ausserwöger, MM Schneider, TW Herling… - Nature Reviews …, 2022 - nature.com
Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

Tie-line analysis reveals interactions driving heteromolecular condensate formation

D Qian, TJ Welsh, NA Erkamp, S Qamar, J Nixon-Abell… - Physical Review X, 2022 - APS
Phase separation of biomolecules gives rise to membraneless organelles that contribute to
the spatiotemporal organization of the cell. In most cases, such biomolecular condensates …

Multidimensional protein solubility optimization with an ultrahigh-throughput microfluidic platform

NA Erkamp, M Oeller, T Sneideris… - Analytical …, 2023 - ACS Publications
Protein-based biologics are highly suitable for drug development as they exhibit low toxicity
and high specificity for their targets. However, for therapeutic applications, biologics must …