Non-specificity as the sticky problem in therapeutic antibody development
Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …
products approved on the market. Successful development of antibody-based drugs …
Tie-line analysis reveals interactions driving heteromolecular condensate formation
Phase separation of biomolecules gives rise to membraneless organelles that contribute to
the spatiotemporal organization of the cell. In most cases, such biomolecular condensates …
the spatiotemporal organization of the cell. In most cases, such biomolecular condensates …
Multidimensional protein solubility optimization with an ultrahigh-throughput microfluidic platform
Protein-based biologics are highly suitable for drug development as they exhibit low toxicity
and high specificity for their targets. However, for therapeutic applications, biologics must …
and high specificity for their targets. However, for therapeutic applications, biologics must …