[HTML][HTML] Biologics, theranostics, and personalized medicine in drug delivery systems

M Puccetti, M Pariano, A Schoubben… - Pharmacological …, 2024 - Elsevier
The progress in human disease treatment can be greatly advanced through the
implementation of nanomedicine. This approach involves targeted and cell-specific therapy …

Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

N Wang, M Chen, T Wang - Journal of Controlled Release, 2019 - Elsevier
Liposomes are widely utilized as a carrier to improve therapeutic efficacy of agents thanks to
their merits of high loading capacity, targeting delivery, reliable protection of agents, good …

Peptide-based synthetic vaccines

M Skwarczynski, I Toth - Chemical science, 2016 - pubs.rsc.org
Classically all vaccines were produced using live or attenuated microorganisms or parts of
them. However, the use of whole organisms, their components or the biological process for …

Developments in vaccine adjuvants

FZ Firdaus, M Skwarczynski, I Toth - Vaccine Design: Methods and …, 2022 - Springer
Vaccines, including subunit, recombinant, and conjugate vaccines, require the use of an
immunostimulator/adjuvant for maximum efficacy. Adjuvants not only enhance the strength …

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Z Sun, H Zhao, L Ma, Y Shi, M Ji, X Sun, D Ma… - Journal of …, 2024 - Springer
Despite recent advancements in cancer treatment, this disease still poses a serious threat to
public health. Vaccines play an important role in preventing illness by preparing the body's …

PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity

AL Silva, PC Soema, B Slütter… - Human vaccines & …, 2016 - Taylor & Francis
Among the emerging subunit vaccines are recombinant protein-and synthetic peptide-based
vaccine formulations. However, proteins and peptides have a low intrinsic immunogenicity …

Head and neck squamous cell carcinoma: risk factors, molecular alterations, immunology and peptide vaccines

Z Sun, X Sun, Z Chen, J Du, Y Wu - International journal of peptide …, 2022 - Springer
Head and neck squamous cell carcinoma (HNSCC) arises from the epithelial lining of the
oral cavity, hypopharynx, oropharynx, and larynx. There are several potential risk factors that …

Immunological principles guiding the rational design of particles for vaccine delivery

KT Gause, AK Wheatley, J Cui, Y Yan, SJ Kent… - ACS …, 2017 - ACS Publications
Despite the immense public health successes of immunization over the past century,
effective vaccines are still lacking for globally important pathogens such as human …

[HTML][HTML] Chemical conjugation strategies for the development of protein-based subunit nanovaccines

L Lu, VT Duong, AO Shalash, M Skwarczynski, I Toth - Vaccines, 2021 - mdpi.com
The production of subunit nanovaccines relies heavily on the development of a vaccine
delivery system that is safe and efficient at delivering antigens to the target site …

[HTML][HTML] Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape

M Durán-Lobato, AM López-Estévez… - Advanced Drug Delivery …, 2021 - Elsevier
Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene
generating a great hope due to their outstanding specificity and potency. However, given …