Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
[HTML][HTML] Technical challenges for FLASH proton therapy
S Jolly, H Owen, M Schippers, C Welsch - Physica Medica, 2020 - Elsevier
There is growing interest in the radiotherapy community in the application of FLASH
radiotherapy, wherein the dose is delivered to the entire treatment volume in less than a …
radiotherapy, wherein the dose is delivered to the entire treatment volume in less than a …
The FLASH effect depends on oxygen concentration
Objective: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy
with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen …
with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen …
Faster and safer? FLASH ultra-high dose rate in radiotherapy
Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier
Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at …
Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at …
FLASH radiotherapy with carbon ion beams
FLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra‐
high dose rates (> 40 Gy/s) have been shown to reduce toxicity in the normal tissue without …
high dose rates (> 40 Gy/s) have been shown to reduce toxicity in the normal tissue without …
Feasibility of proton FLASH effect tested by zebrafish embryo irradiation
Background and purpose Motivated by first animal trials showing the normal tissue
protecting effect of electron and photon Flash irradiation, ie at mean dose rates of 100 Gy/s …
protecting effect of electron and photon Flash irradiation, ie at mean dose rates of 100 Gy/s …
A quantitative analysis of the role of oxygen tension in FLASH radiation therapy
Purpose Recent demonstrations of normal tissue sparing by high-dose, high-dose-rate
FLASH radiation therapy have driven considerable interest in its application to improve …
FLASH radiation therapy have driven considerable interest in its application to improve …
Model studies of the role of oxygen in the FLASH effect
Current radiotherapy facilities are standardized to deliver dose rates around 0.1–0.4 Gy/s in
2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit …
2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit …
FLASH investigations using protons: design of delivery system, preclinical setup and confirmation of FLASH effect with protons in animal systems
Q Zhang, E Cascio, C Li, Q Yang… - Radiation …, 2020 - meridian.allenpress.com
Extremely high-dose-rate irradiation, referred to as FLASH, has been shown to be less
damaging to normal tissues than the same dose administrated at conventional dose rates …
damaging to normal tissues than the same dose administrated at conventional dose rates …