In this Review, we describe the pathogenesis, diagnosis and management of primary
hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a …

Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

Objective: This report summarizes data on traditional and nontraditional manifestations of
primary hyperparathyroidism (PHPT) that have been published since the last International …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling
(canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the …

Context: Sclerostin, a Wnt antagonist produced by osteocytes, regulates osteoblast activity
and is a well-established key player in bone turnover. Recent data indicate that the Wnt …

For more than a decade, the Wnt–β-catenin pathway has been the focus of intense basic
and clinical research in the bone field because of its importance in skeletal development …

Abnormalities of bone metabolism and increased vascular calcification are common in
chronic kidney disease (CKD) and important causes of morbidity and mortality. The Wnt …

A healthy skeleton depends on a continuous renewal and maintenance of the bone tissue.
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …

Sclerostin regulates bone formation by inhibiting Wnt pathway signaling. Low circulating
sclerostin levels cause high bone mass. We hypothesized that postmenopausal women with …