Protein phosphatase 2A: a target for anticancer therapy
Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
Protein phosphatase 2A regulatory subunits and cancer
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …
integral role in the regulation of a number of major signaling pathways whose deregulation …
Fractionated radiation therapy stimulates antitumor immunity mediated by both resident and infiltrating polyclonal T-cell populations when combined with PD-1 …
SJ Dovedi, EJ Cheadle, AL Popple, E Poon… - Clinical Cancer …, 2017 - AACR
Purpose: Radiotherapy is a highly effective anticancer treatment forming part of the standard
of care for the majority of patients, but local and distal disease recurrence remains a major …
of care for the majority of patients, but local and distal disease recurrence remains a major …
Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism
Extensive studies have revealed that berberine, a small molecule derived from Coptidis
rhizoma (Huanglian in Chinese) and many other plants, has strong anti‐tumor properties. To …
rhizoma (Huanglian in Chinese) and many other plants, has strong anti‐tumor properties. To …
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia
P Neviani, R Santhanam, JJ Oaks… - The Journal of …, 2007 - Am Soc Clin Investig
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome–
positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal BCR/ABL-driven …
positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal BCR/ABL-driven …
[HTML][HTML] The emerging role of FTY720 (Fingolimod) in cancer treatment
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple
sclerosis that sequesters T-cells to lymph nodes through functional antagonism of …
sclerosis that sequesters T-cells to lymph nodes through functional antagonism of …
Regulatory B cells accelerate hepatocellular carcinoma progression via CD40/CD154 signaling pathway
Y Shao, CM Lo, CC Ling, XB Liu, KTP Ng, ACY Chu… - Cancer letters, 2014 - Elsevier
Human hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a
poor prognosis of limited survival. The role of regulatory B cell (Breg), a new important B cell …
poor prognosis of limited survival. The role of regulatory B cell (Breg), a new important B cell …
Targeting the sphingosine kinase/sphingosine-1-phosphate signaling axis in drug discovery for cancer therapy
Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …
signaling pathways controlled by human kinases has often been observed in various human …
miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma
Q Zhu, Z Wang, Y Hu, J Li, X Li, L Zhou… - Oncology …, 2012 - spandidos-publications.com
Distant migration and invasion is the main contributor to the death of cancer patients and
miRNAs have been implicated in these processes. In the present study, we identified the …
miRNAs have been implicated in these processes. In the present study, we identified the …
Multiple sclerosis and cancer: the ying-yang effect of disease modifying therapies
Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the
rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS …
rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS …