The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Ferroptosis is a vital driver of pathophysiological consequences of Alzheimer's disease (AD).
High-efficiency pharmacological inhibition of ferroptosis requires comprehensive …

Iron deficiency is a common condition increasingly diagnosed and treated by
gastroenterologists. The most common presentation of iron deficiency is anaemia; however …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Proteins can become oxidatively modified in many different ways, either by direct oxidation
of amino acid side chains and protein backbone or indirectly by conjugation with oxidation …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Iron is one of the most important elements for life, but excess iron is toxic. Intracellularly,
mitochondria are the center of iron utilization requiring sufficient amounts to maintain normal …

Iron is the most abundant transition metal in the earth's crust. It cycles easily between ferric
(oxidized; Fe (III)) and ferrous (reduced; Fe (II)) and readily forms complexes with oxygen …

Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …