A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …

During a decade of proof-of-principle analysis in model organisms, protein networks have
been used to further the study of molecular evolution, to gain insight into the robustness of …

Recent genome sequencing studies have shown that the somatic mutations that drive
cancer development are distributed across a large number of genes. This mutational …

Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused
by a complex interplay of genetic and environmental factors. Information on various aspects …

Motivation: Understanding the association between genetic diseases and their causal genes
is an important problem concerning human health. With the recent influx of high-throughput …

Systems biology provides a framework for assembling models of biological systems from
systematic measurements. Since the field was first introduced a decade ago, considerable …

Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …

The genomic era has been characterised by vast amounts of data from diverse sources,
creating a need for new tools to extract biologically meaningful information. Bioinformatics is …

The recently proposed concept of molecular connectivity maps enables researchers to
integrate experimental measurements of genes, proteins, metabolites, and drug compounds …