The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain.
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …

The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily
on the responses of the neurovascular unit. Here, we report the development and …

Ischemic stroke, which is the second highest cause of death and the leading cause of
disability, represents~ 71% of all strokes globally. Some studies have found that the key …

Microglia, the resident macrophages of the brain, are highly plastic and well known to be pre-
activated or 'primed'by active inflammatory processes, resulting in amplified responses to a …

Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …

Microglia have been recognized as macrophages of the central nervous system (CNS) that
are regarded as a culprit of neuroinflammation in neurodegenerative diseases. Thus …

Microglia are resident immune cells in the brain and play a central role in the development
and surveillance of the nervous system. Extensive gliosis is a common pathological feature …

Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune
cells. Despite the central role for microglia in neuroinflammation and neurodegeneration …