Aortic valve disease and treatment: the need for naturally engineered solutions
The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …
arterial system. The natural anatomical geometry and microstructural complexity ensures …
Mitochondrial dysfunction: a basic mechanism in inflammation‐related non‐communicable diseases and therapeutic opportunities
Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or
excessive energy intake that encompasses the linkage of inflammation, oxidation, and …
excessive energy intake that encompasses the linkage of inflammation, oxidation, and …
[PDF][PDF] Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …
Ceramide as a mediator of non-alcoholic fatty liver disease and associated atherosclerosis
Cardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease
(NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide …
(NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide …
Pathobiology of aging mice and GEM: background strains and experimental design
CF Brayton, PM Treuting, JM Ward - Veterinary pathology, 2012 - journals.sagepub.com
The use of induced and spontaneous mutant mice and genetically engineered mice (and
combinations thereof) to study cancers and other aging phenotypes to advance improved …
combinations thereof) to study cancers and other aging phenotypes to advance improved …
Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract
S Fernández-Arroyo, IC Rodríguez-Medina… - Food research …, 2011 - Elsevier
In the present study the quantification of the polyphenolic fraction, anthocyanins and other
polar compounds, the antioxidant capacity and the anti-hyperlipemic action of the aqueous …
polar compounds, the antioxidant capacity and the anti-hyperlipemic action of the aqueous …
Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice
BACKGROUND: MicroRNAs have the potential for clinical application. Probable modulation
by plant-derived polyphenols might open preventive measures using simple dietary …
by plant-derived polyphenols might open preventive measures using simple dietary …
Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease
Nonalcoholic fatty liver disease is considered to be the hepatic manifestation of metabolic
syndrome and is usually related to high-fat, high-cholesterol diets. With the rationale that the …
syndrome and is usually related to high-fat, high-cholesterol diets. With the rationale that the …
Utility of human relevant preclinical animal models in navigating NAFLD to MAFLD paradigm
Fatty liver disease is an emerging contributor to disease burden worldwide. The past
decades of work established the heterogeneous nature of non-alcoholic fatty liver disease …
decades of work established the heterogeneous nature of non-alcoholic fatty liver disease …
Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms
Background There is growing evidence that natural products, mostly plant-derived
polyphenols, are important in the relationship between nutrients and health in humans …
polyphenols, are important in the relationship between nutrients and health in humans …