Age-related macular degeneration is a major cause of blindness worldwide. With ageing
populations in many countries, more than 20% might have the disorder. Advanced age …

Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …

Hidden Markov models—most often abbreviated to the acronym “HMMs”—are one of the
most successful statistical modelling ideas that have came up in the last forty years: the use …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

In Chap. 10, we presented linear models (LMs) models with fixed effects for correlated data.
They are examples of population-averaged models, because their mean-structure …

Missing Data in Clinical Studies provides a comprehensive account of the problems arising
when data from clinical and related studies are incomplete, and presents the reader with …

The validation of surrogate endpoints has been studied by Prentice (1989). He presented a
definition as well as a set of criteria, which are equivalent only if the surrogate and true …

Age-related macular degeneration, a deterioration of the central portion of the retina, is the
chief cause of severe and irreversible loss of vision in developed countries. 1, 2 There is no …

The validation of surrogate endpoints has been studied by Prentice (1989, Statistics in
Medicine 8, 431-440) and Freedman, Graubard, and Schatzkin (1992, Statistics in Medicine …

Both humanitarian and commercial considerations have spurred intensive search for
methods to reduce the time and cost required to develop new therapies. The identification …