Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …
only three out of four patients with Parkinson's disease, and tremor-dominant patients …
High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor
It has been hypothesized that in Parkinson's disease (PD) there is increased
synchronization of neuronal firing in the basal ganglia. This study examines the discharge …
synchronization of neuronal firing in the basal ganglia. This study examines the discharge …
Stimulating at the right time: phase-specific deep brain stimulation
Abstract See Moll and Engel (doi: 10.1093/aww308) for a scientific commentary on this
article. Brain regions dynamically engage and disengage with one another to execute …
article. Brain regions dynamically engage and disengage with one another to execute …
Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine vervet …
To investigate the role of the basal ganglia in parkinsonian tremor, we recorded hand tremor
and simultaneous activity of several neurons in the external and internal segments of the …
and simultaneous activity of several neurons in the external and internal segments of the …
The pathophysiology of tremor
Tremor is defined as rhythmic oscillatory activity of body parts. Four physiological basic
mechanisms for such oscillatory activity have been described: mechanical oscillations; …
mechanisms for such oscillatory activity have been described: mechanical oscillations; …
The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics
MC Rodriguez-Oroz, M Rodriguez, J Guridi, K Mewes… - Brain, 2001 - academic.oup.com
Single-cell recording of the subthalamic nucleus (STN) was undertaken in 14 patients with
Parkinson's disease submitted to surgery. Three hundred and fifty neurones were recorded …
Parkinson's disease submitted to surgery. Three hundred and fifty neurones were recorded …
Synchronized neural oscillations and the pathophysiology of Parkinson's disease
Oscillatory activities across multiple frequency bands and their cross-frequency interactions
within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to …
within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to …
Pathophysiology of Parkinson's disease: from clinical neurology to basic neuroscience and back
Parkinson's disease (PD) is characterized by motor and nonmotor (cognitive and limbic)
deficits. The motor signs of PD include hypokinetic signs such as akinesia/bradykinesia …
deficits. The motor signs of PD include hypokinetic signs such as akinesia/bradykinesia …
Cerebello-cortical network fingerprints differ between essential, Parkinson's and mimicked tremors
Cerebello-thalamo-cortical loops play a major role in the emergence of pathological tremors
and voluntary rhythmic movements. It is unclear whether these loops differ anatomically or …
and voluntary rhythmic movements. It is unclear whether these loops differ anatomically or …