Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types

M Cogliati - Scientifica, 2013 - Wiley Online Library
Cryptococcosis is a fungal disease affecting more than one million people per year
worldwide. The main etiological agents of cryptococcosis are the two sibling species …

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

CA Desjardins, C Giamberardino, SM Sykes… - Genome …, 2017 - genome.cshlp.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

SK Esher, O Zaragoza, JA Alspaugh - Memorias do Instituto Oswaldo …, 2018 - SciELO Brasil
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

A new lineage of Cryptococcus gattii (VGV) discovered in the Central Zambezian Miombo Woodlands

RA Farrer, M Chang, MJ Davis, L van Dorp, DH Yang… - MBio, 2019 - Am Soc Microbiol
We discovered a new lineage of the globally important fungal pathogen Cryptococcus gattii
on the basis of analysis of six isolates collected from three locations spanning the Central …

Gene expression of diverse Cryptococcus isolates during infection of the human central nervous system

CH Yu, P Sephton-Clark, JL Tenor, DL Toffaletti… - Mbio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen
causing considerable morbidity and mortality. In this study, we provide the widest view to …

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

J Rhodes, CA Desjardins, SM Sykes, MA Beale… - Genetics, 2017 - academic.oup.com
Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a
significant source of mortality in immunocompromised individuals, typically human …

Cryptococcus neoformans and Cryptococcus gattii Species Complexes in Latin America: A Map of Molecular Types, Genotypic Diversity, and Antifungal …

C Firacative, W Meyer, E Castañeda - Journal of Fungi, 2021 - mdpi.com
Cryptococcosis, a potentially fatal mycosis, is caused by members of the Cryptococcus
neoformans and Cryptococcus gattii species complexes. In Latin America, cryptococcal …

Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa

MA Beale, W Sabiiti, EJ Robertson… - PLoS neglected …, 2015 - journals.plos.org
Cryptococcal meningitis is a major cause of mortality throughout the develo** world, yet
little is known about the genetic markers underlying Cryptococcal virulence and patient …

A population genomics approach to assessing the genetic basis of within-host microevolution underlying recurrent cryptococcal meningitis infection

J Rhodes, MA Beale, M Vanhove… - G3: Genes …, 2017 - academic.oup.com
Recurrence of meningitis due to Cryptococcus neoformans after treatment causes
substantial mortality in HIV/AIDS patients across sub-Saharan Africa. In order to determine …