Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Andrographolide, a natural anti-inflammatory agent: An Update

X Li, W Yuan, J Wu, J Zhen, Q Sun, M Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …

N Braidy, J Berg, J Clement, F Khorshidi… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

V Shoshan-Barmatz, E Nahon-Crystal… - Pharmacological …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

M Perluigi, F Di Domenico, DA Butterfield - Neurobiology of disease, 2015 - Elsevier
Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

[HTML][HTML] Natural acetylcholinesterase inhibitors: a multi-targeted therapeutic potential in Alzheimer's disease

K Gajendra, GK Pratap, DV Poornima… - European Journal of …, 2024 - Elsevier
Abstract Alzheimer's disease (AD), the main dementia type accounting for over 70% of the
entire dementia population, progressive decline in memory and executive function. AD …

Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK‐3β/β‐catenin signaling pathway

Y Yang, L Wang, C Zhang, Y Guo, J Li… - Chemical Biology & …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that can cause cognitive
impairment. Ginsenoside Rg1 (Rg1) has a significant neuroprotective effect on animals with …

Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action

WSD Tan, W Liao, S Zhou, WSF Wong - Biochemical pharmacology, 2017 - Elsevier
Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …